Assay Detail
Functional
CHEMBL650776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autophosphorylation of the two-component signal transduction system kinase was measured using the KinA/Spo0F regulatory system of Bacillus subtilis.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bacillus subtilis |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
KinA/Spo0F (sporulation kinase A/sporulation initiation phosphotransferase F) (CHEMBL2111331) ↗| Type | PROTEIN FAMILY |
| Organism | Bacillus subtilis (strain 168) |
Publication
Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.77 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327734 | — | — | 1 | 5.55 |
| CHEMBL12131 | CLOSANTEL | 2.0 | 1 | 5.42 |
| CHEMBL98026 | — | — | 1 | 5.32 |
| CHEMBL101786 | — | — | 1 | 5.05 |
| CHEMBL100719 | — | — | 1 | 5.02 |
| CHEMBL98273 | — | — | 1 | 4.72 |
| CHEMBL57656 | — | — | 1 | 4.68 |
| CHEMBL431272 | — | — | 1 | 4.57 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | 4.0 | 1 | 4.35 |
| CHEMBL319252 | — | — | 1 | 4.30 |
| CHEMBL100688 | — | — | 1 | 4.17 |
| CHEMBL99708 | — | — | 1 | 4.07 |
| CHEMBL299692 | — | — | 1 | - |
| CHEMBL330654 | — | — | 1 | - |
| CHEMBL318371 | — | — | 1 | - |
| CHEMBL319852 | — | — | 1 | - |
| CHEMBL431816 | — | — | 1 | - |
| CHEMBL101264 | — | — | 1 | - |
| CHEMBL98743 | — | — | 1 | - |
| CHEMBL100633 | — | — | 1 | - |
| CHEMBL419162 | — | — | 1 | - |
| CHEMBL97945 | — | — | 1 | - |
| CHEMBL330397 | — | — | 1 | - |
| CHEMBL319962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327734 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL98026 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL101786 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL100719 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL98273 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL57656 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL431272 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL291338 | 3,3',4',5-TETRACHLOROSALICYLANILIDE | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL319252 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL100688 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL99708 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL299692 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL330654 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL318371 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL319852 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL431816 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL101264 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL98743 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL100633 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL419162 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL97945 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL330397 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL319962 | — | IC50 | > | 500000.0 | nM | - |