Assay Detail
Functional
CHEMBL650882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity for Beta-2 adrenergic receptor was assessed by it's inhibitory effect on spontaneous contractions in isolated rat uterus
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Uterus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.14 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 10.00 |
| CHEMBL284782 | — | — | 1 | 8.04 |
| CHEMBL544427 | — | — | 1 | 6.28 |
| CHEMBL2079599 | — | — | 1 | 4.22 |
| CHEMBL2079543 | — | — | 1 | - |
| CHEMBL3349532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL284782 | — | IC50 | = | 9.12 | nM | 8.04 |
| CHEMBL544427 | — | IC50 | = | 524.81 | nM | 6.28 |
| CHEMBL2079599 | — | IC50 | = | 59979.11 | nM | 4.22 |
| CHEMBL2079543 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3349532 | — | IC50 | > | 100000.0 | nM | - |