Assay Detail
Functional
CHEMBL650917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
ability to directly depolarize CA1 pyramidal neurons of rat hyppocampal slices after reversal with L-alpha-AA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pyramidal neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.64 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126608 | — | — | 1 | 4.70 |
| CHEMBL279956 | QUISQUALATE | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126608 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL279956 | QUISQUALATE | IC50 | = | 26000.0 | nM | 4.58 |