Assay Detail
Functional
CHEMBL651090
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Antiproliferative activity measured against murine B16 melanoma cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.30 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350563 | — | — | 1 | 6.32 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 6.32 |
| CHEMBL3350557 | — | — | 1 | 6.05 |
| CHEMBL3350561 | — | — | 1 | 5.30 |
| CHEMBL3350559 | — | — | 1 | 5.10 |
| CHEMBL3350564 | — | — | 1 | 4.89 |
| CHEMBL3350565 | — | — | 1 | 4.76 |
| CHEMBL3350562 | — | — | 1 | 4.51 |
| CHEMBL3350558 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350563 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3350557 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3350561 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3350559 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3350564 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3350565 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL3350562 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3350558 | — | IC50 | = | 35000.0 | nM | 4.46 |