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Assay Detail

CHEMBL651150

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration required for 50% inhibition of binding against Angiotensin II receptor in the rat adrenal cortex tissue
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Adrenal cortex
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094112)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

2,3,6-Substituted quinazolinones as angiotensin II receptor antagonists
Levin J, Venkatesan A, Chan P, Baker J, Francisco G, Bailey T, Vice G, Katocs A, Lai F, Coupet J
Bioorg Med Chem Lett (1994) 4 : 1135 -1140
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.01 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL15118 1 5.30
CHEMBL416714 1 5.22
CHEMBL15154 1 5.16
CHEMBL14748 1 5.05
CHEMBL274466 1 5.05
CHEMBL15225 1 5.05
CHEMBL15214 1 5.00
CHEMBL422756 1 5.00
CHEMBL15141 1 4.92
CHEMBL14487 1 4.85
CHEMBL14507 1 4.82
CHEMBL14951 1 4.75
CHEMBL415983 1 -
CHEMBL275875 CL-329167 1 -
CHEMBL15283 1 -
CHEMBL191 LOSARTAN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL15118 IC50 = 5000.0 nM 5.30
CHEMBL416714 IC50 = 6000.0 nM 5.22
CHEMBL15154 IC50 = 7000.0 nM 5.16
CHEMBL14748 IC50 = 9000.0 nM 5.05
CHEMBL274466 IC50 = 9000.0 nM 5.05
CHEMBL15225 IC50 = 9000.0 nM 5.05
CHEMBL15214 IC50 = 10000.0 nM 5.00
CHEMBL422756 IC50 = 10000.0 nM 5.00
CHEMBL15141 IC50 = 12000.0 nM 4.92
CHEMBL14487 IC50 = 14000.0 nM 4.85
CHEMBL14507 IC50 = 15000.0 nM 4.82
CHEMBL14951 IC50 = 18000.0 nM 4.75
CHEMBL415983 IC50 = 1000000.0 nM -
CHEMBL275875 CL-329167 IC50 = 6000.0 nM -
CHEMBL15283 IC50 = 1000000.0 nM -
CHEMBL191 LOSARTAN IC50 = 82000.0 nM -