Assay Detail
Binding
CHEMBL651155
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Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Nonpeptide angiotensin II receptor antagonists. Synthesis, in vitro activity, and molecular modeling studies of N-[(heterobiaryl)methyl] imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.27 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274447 | — | — | 1 | 6.46 |
| CHEMBL129225 | — | — | 1 | 5.48 |
| CHEMBL340682 | — | — | 1 | 5.17 |
| CHEMBL339044 | — | — | 1 | 5.01 |
| CHEMBL129170 | — | — | 1 | 5.01 |
| CHEMBL125621 | — | — | 1 | 4.94 |
| CHEMBL129006 | — | — | 1 | 4.84 |
| CHEMBL129336 | — | — | 1 | - |
| CHEMBL129005 | — | — | 1 | - |
| CHEMBL125789 | — | — | 1 | - |
| CHEMBL128291 | — | — | 1 | - |
| CHEMBL50135 | — | — | 1 | - |
| CHEMBL127108 | — | — | 1 | - |
| CHEMBL125790 | — | — | 1 | - |
| CHEMBL338840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274447 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL129225 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL340682 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL339044 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL129170 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL125621 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL129006 | — | Ki | = | 14500.0 | nM | 4.84 |
| CHEMBL129336 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL129005 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL125789 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL128291 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL50135 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL127108 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL125790 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL338840 | — | Ki | > | 10000.0 | nM | - |