Assay Detail
Functional
CHEMBL651274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of proliferation of EGF-dependent BALB/MK cells.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Balb/MK |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.81 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 6.70 |
| CHEMBL121796 | — | — | 1 | 6.52 |
| CHEMBL121954 | — | — | 1 | 6.34 |
| CHEMBL118130 | — | — | 1 | 6.25 |
| CHEMBL332906 | — | — | 1 | 6.11 |
| CHEMBL123189 | — | — | 1 | 6.09 |
| CHEMBL119977 | — | — | 1 | 6.09 |
| CHEMBL122245 | — | — | 1 | 6.07 |
| CHEMBL332882 | — | — | 1 | 6.03 |
| CHEMBL120979 | — | — | 1 | 6.02 |
| CHEMBL331906 | — | — | 1 | 6.00 |
| CHEMBL122411 | — | — | 1 | 5.99 |
| CHEMBL122182 | — | — | 1 | 5.97 |
| CHEMBL333038 | — | — | 1 | 5.85 |
| CHEMBL120319 | — | — | 1 | 5.84 |
| CHEMBL332765 | — | — | 1 | 5.81 |
| CHEMBL332971 | — | — | 1 | 5.80 |
| CHEMBL121260 | — | — | 1 | 5.59 |
| CHEMBL120069 | — | — | 1 | 5.57 |
| CHEMBL122068 | — | — | 1 | 5.54 |
| CHEMBL333231 | — | — | 1 | 5.50 |
| CHEMBL420885 | — | — | 1 | 5.37 |
| CHEMBL332333 | — | — | 1 | 5.08 |
| CHEMBL121190 | — | — | 1 | 4.85 |
| CHEMBL119982 | — | — | 1 | 4.30 |
| CHEMBL120703 | — | — | 1 | - |
| CHEMBL334026 | — | — | 1 | - |
| CHEMBL332612 | — | — | 1 | - |
| CHEMBL118904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL121796 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL121954 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL118130 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL332906 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL123189 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL119977 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL122245 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL332882 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL120979 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL331906 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL122411 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL122182 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL333038 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL120319 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL332765 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL332971 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL121260 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL120069 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL122068 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL333231 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL420885 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL332333 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL121190 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL119982 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL120703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL334026 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL332612 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118904 | — | IC50 | > | 50000.0 | nM | - |