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Assay Detail

CHEMBL651275

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Functional
Inhibition of proliferation of EGF-dependent BALB/MK cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Balb/MK
Confidence 1 — Organism
Curated By Expert

Target

Balb/MK (CHEMBL614065)
Type CELL-LINE
Organism Mus musculus

Publication

4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase.
Traxler PM, Furet P, Mett H, Buchdunger E, Meyer T, Lydon N.
J Med Chem (1996) 39 : 2285 -2292
PubMed 8691423 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.35 6.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL306315 1 6.33
CHEMBL75177 1 6.01
CHEMBL72393 1 5.85
CHEMBL306081 1 5.85
CHEMBL74722 1 5.85
CHEMBL307026 1 5.14
CHEMBL433305 1 4.89
CHEMBL75049 1 4.61
CHEMBL308582 1 4.52
CHEMBL308593 1 4.42
CHEMBL307062 1 -
CHEMBL307209 1 -
CHEMBL311129 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL306315 IC50 = 470.0 nM 6.33
CHEMBL75177 IC50 = 980.0 nM 6.01
CHEMBL72393 IC50 = 1400.0 nM 5.85
CHEMBL306081 IC50 = 1400.0 nM 5.85
CHEMBL74722 IC50 = 1400.0 nM 5.85
CHEMBL307026 IC50 = 7200.0 nM 5.14
CHEMBL433305 IC50 = 12800.0 nM 4.89
CHEMBL75049 IC50 = 24600.0 nM 4.61
CHEMBL308582 IC50 = 29900.0 nM 4.52
CHEMBL308593 IC50 = 38300.0 nM 4.42
CHEMBL307062 IC50 > 50000.0 nM -
CHEMBL307209 IC50 > 50000.0 nM -
CHEMBL311129 IC50 > 50000.0 nM -