Assay Detail
Functional
CHEMBL651283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human breast cancer cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.52 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22403 | — | — | 1 | 5.21 |
| CHEMBL416373 | — | — | 1 | 4.80 |
| CHEMBL278847 | — | — | 1 | 4.60 |
| CHEMBL22327 | — | — | 1 | 4.50 |
| CHEMBL22139 | — | — | 1 | 4.25 |
| CHEMBL21885 | — | — | 1 | 4.25 |
| CHEMBL21395 | — | — | 1 | 4.00 |
| CHEMBL416376 | — | — | 1 | - |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | - |
| CHEMBL22693 | — | — | 1 | - |
| CHEMBL278813 | — | — | 1 | - |
| CHEMBL25112 | — | — | 1 | - |
| CHEMBL22148 | — | — | 1 | - |
| CHEMBL416552 | — | — | 1 | - |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
| CHEMBL22901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22403 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL416373 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL278847 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL22327 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL22139 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL21885 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL21395 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL416376 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC50 | > | 250000.0 | nM | - |
| CHEMBL22693 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL278813 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL25112 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL22148 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL416552 | — | IC50 | = | 268000.0 | nM | - |
| CHEMBL22 | TRIMETHOPRIM | IC50 | > | 250000.0 | nM | - |
| CHEMBL22901 | — | IC50 | = | 139000.0 | nM | - |