Assay Detail
Functional
CHEMBL651284
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In vitro cytotoxicity against Plasmodium falciparum infected BC cell line.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.09 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21921 | — | — | 1 | 5.80 |
| CHEMBL346963 | — | — | 1 | 5.75 |
| CHEMBL161009 | — | — | 1 | 5.66 |
| CHEMBL278813 | — | — | 1 | 5.52 |
| CHEMBL352441 | — | — | 1 | 5.44 |
| CHEMBL22403 | — | — | 1 | 5.31 |
| CHEMBL161451 | — | — | 1 | 5.28 |
| CHEMBL348151 | — | — | 1 | 5.19 |
| CHEMBL352195 | — | — | 1 | 5.16 |
| CHEMBL161117 | — | — | 1 | 5.08 |
| CHEMBL161034 | — | — | 1 | 5.07 |
| CHEMBL7130 | — | — | 1 | 5.05 |
| CHEMBL346932 | — | — | 1 | 5.02 |
| CHEMBL444605 | — | — | 1 | 5.00 |
| CHEMBL161757 | — | — | 1 | 5.00 |
| CHEMBL159052 | — | — | 1 | 5.00 |
| CHEMBL158570 | — | — | 1 | 5.00 |
| CHEMBL422005 | — | — | 1 | 4.82 |
| CHEMBL354011 | — | — | 1 | 4.66 |
| CHEMBL346982 | — | — | 1 | 4.52 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.40 |
| CHEMBL158639 | — | — | 1 | 4.19 |
| CHEMBL329687 | — | — | 1 | - |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | - |
| CHEMBL416552 | — | — | 1 | - |
| CHEMBL22693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21921 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL346963 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL161009 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL278813 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL352441 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL22403 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL161451 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL348151 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL352195 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL161117 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL161034 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL7130 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL346932 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL444605 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL161757 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL159052 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL158570 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL422005 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL354011 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL346982 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL158639 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL329687 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL747 | CYCLOGUANIL | IC50 | > | 50000.0 | nM | - |
| CHEMBL416552 | — | IC50 | = | 268000.0 | nM | - |
| CHEMBL22693 | — | IC50 | = | 250000.0 | nM | - |