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Assay Detail

CHEMBL651286

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Functional
Cytotoxicity against BC cells.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BC
Confidence 1 — Organism
Curated By Expert

Target

BC (CHEMBL613535)
Type CELL-LINE

Publication

C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.
Ekthawatchai S, Kamchonwongpaisan S, Kongsaeree P, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y.
J Med Chem (2001) 44 : 4688 -4695
PubMed 11741486 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.36 6.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3037951 1 6.44
CHEMBL3037950 1 5.96
CHEMBL140321 1 5.92
CHEMBL344792 1 5.92
CHEMBL346384 1 5.89
CHEMBL2111997 1 5.80
CHEMBL2112834 1 5.80
CHEMBL141328 1 5.70
CHEMBL2368096 1 5.62
CHEMBL385701 1 5.55
CHEMBL358618 1 5.46
CHEMBL3037989 1 5.30
CHEMBL3037983 1 5.24
CHEMBL3037984 1 5.21
CHEMBL348016 1 5.13
CHEMBL386761 1 5.02
CHEMBL3037986 1 4.96
CHEMBL2368095 1 4.89
CHEMBL3037988 1 4.85
CHEMBL347736 1 4.44
CHEMBL3037995 1 4.39
CHEMBL3037987 1 4.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3037951 IC50 = 360.0 nM 6.44
CHEMBL3037950 IC50 = 1100.0 nM 5.96
CHEMBL140321 IC50 = 1200.0 nM 5.92
CHEMBL344792 IC50 = 1200.0 nM 5.92
CHEMBL346384 IC50 = 1300.0 nM 5.89
CHEMBL2111997 IC50 = 1600.0 nM 5.80
CHEMBL2112834 IC50 = 1600.0 nM 5.80
CHEMBL141328 IC50 = 2000.0 nM 5.70
CHEMBL2368096 IC50 = 2400.0 nM 5.62
CHEMBL385701 IC50 = 2800.0 nM 5.55
CHEMBL358618 IC50 = 3500.0 nM 5.46
CHEMBL3037989 IC50 = 5000.0 nM 5.30
CHEMBL3037983 IC50 = 5700.0 nM 5.24
CHEMBL3037984 IC50 = 6200.0 nM 5.21
CHEMBL348016 IC50 = 7400.0 nM 5.13
CHEMBL386761 IC50 = 9600.0 nM 5.02
CHEMBL3037986 IC50 = 11000.0 nM 4.96
CHEMBL2368095 IC50 = 13000.0 nM 4.89
CHEMBL3037988 IC50 = 14000.0 nM 4.85
CHEMBL347736 IC50 = 36000.0 nM 4.44
CHEMBL3037995 IC50 = 41000.0 nM 4.39
CHEMBL3037987 IC50 = 41000.0 nM 4.39