Assay Detail
Binding
CHEMBL651293
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Inhibitory activity against Bcl-2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.41 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436605 | ANTIMYCIN A3 | — | 1 | 5.70 |
| CHEMBL334590 | — | — | 1 | 5.48 |
| CHEMBL137135 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436605 | ANTIMYCIN A3 | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL334590 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL137135 | — | IC50 | = | 9000.0 | nM | 5.05 |