Assay Detail
Binding
CHEMBL651364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from CHO-K1 cell membranes expressing human dopamine receptor D2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.03 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.36 |
| CHEMBL340211 | AZAPERONE | 2.0 | 1 | 7.28 |
| CHEMBL129237 | — | — | 1 | 7.14 |
| CHEMBL339963 | — | — | 1 | 7.00 |
| CHEMBL129159 | — | — | 1 | 6.55 |
| CHEMBL339033 | — | — | 1 | 6.39 |
| CHEMBL60859 | BMY-14802 | — | 1 | 5.47 |
| CHEMBL129768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL340211 | AZAPERONE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL129237 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL339963 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL129159 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL339033 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL60859 | BMY-14802 | Ki | = | 3346.0 | nM | 5.47 |
| CHEMBL129768 | — | Ki | > | 5000.0 | nM | - |