Assay Detail
Binding
CHEMBL651365
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Displacement of [3H]-spiperone from CHO-K1 cell membranes expressing human dopamine 3 receptors
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.00 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.02 |
| CHEMBL340211 | AZAPERONE | 2.0 | 1 | 7.28 |
| CHEMBL339963 | — | — | 1 | 6.90 |
| CHEMBL129237 | — | — | 1 | 6.48 |
| CHEMBL339033 | — | — | 1 | 6.43 |
| CHEMBL129159 | — | — | 1 | 5.89 |
| CHEMBL129768 | — | — | 1 | - |
| CHEMBL60859 | BMY-14802 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL340211 | AZAPERONE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL339963 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL129237 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL339033 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL129159 | — | Ki | = | 1296.0 | nM | 5.89 |
| CHEMBL129768 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL60859 | BMY-14802 | Ki | > | 2000.0 | nM | - |