Assay Detail
Binding
CHEMBL651446
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Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKA in mouse pancreatic membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cholecystokinin analogues: The ergopeptine alkaloids as models of the active conformation of CCK
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.95 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278032 | — | — | 1 | 5.46 |
| CHEMBL18727 | — | — | 1 | 4.92 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 1 | 4.47 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 1 | - |
| CHEMBL1403281 | ERGOCRYPTINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278032 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL18727 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | > | 80000.0 | nM | - |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | > | 80000.0 | nM | - |