Assay Detail
Binding
CHEMBL651484
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Displacement of 3[H]Flunitrazepam from GABA-A central benzodiazepine receptor of bovine brain membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Subcellular | Brain membranes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.76 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297126 | — | — | 1 | 7.16 |
| CHEMBL49558 | — | — | 1 | 7.05 |
| CHEMBL45788 | — | — | 1 | 7.00 |
| CHEMBL299156 | — | — | 1 | 5.96 |
| CHEMBL45871 | — | — | 1 | 5.94 |
| CHEMBL48374 | — | — | 1 | 5.82 |
| CHEMBL47336 | — | — | 1 | 5.52 |
| CHEMBL416648 | — | — | 1 | 5.52 |
| CHEMBL48989 | — | — | 1 | 5.51 |
| CHEMBL290037 | — | — | 1 | 4.68 |
| CHEMBL297272 | — | — | 1 | 4.52 |
| CHEMBL297153 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297126 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL49558 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL45788 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL299156 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL45871 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL48374 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL47336 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL416648 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL48989 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL290037 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL297272 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL297153 | — | IC50 | = | 39000.0 | nM | 4.41 |