Assay Detail
Binding
CHEMBL651545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for inhibition of [125I]AII to rat uterine membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85595 | — | — | 1 | 8.25 |
| CHEMBL315022 | — | — | 1 | 8.17 |
| CHEMBL315021 | FORASARTAN | 2.0 | 1 | 8.16 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.44 |
| CHEMBL86344 | — | — | 1 | 7.01 |
| CHEMBL88067 | — | — | 1 | 6.96 |
| CHEMBL87411 | — | — | 1 | 6.82 |
| CHEMBL87655 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85595 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL315022 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL315021 | FORASARTAN | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL191 | LOSARTAN | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL86344 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL88067 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL87411 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL87655 | — | IC50 | = | 250.0 | nM | 6.60 |