Assay Detail
Binding
CHEMBL651546
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Tested for binding affinity by measuring displacement of [125I]-Sar1 Ile8 angiotensin II from rat adrenal cortical membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, Biological Properties, and Structure-Activity Relationships of Quinoxaline Angiotensin II Receptor Antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.22 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89917 | — | — | 1 | 8.68 |
| CHEMBL422954 | — | — | 1 | 8.59 |
| CHEMBL91507 | — | — | 1 | 8.16 |
| CHEMBL88142 | — | — | 1 | 8.15 |
| CHEMBL330062 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89917 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL422954 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL91507 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL88142 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL330062 | — | Ki | = | 29.0 | nM | 7.54 |