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Assay Detail

CHEMBL651552

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Binding
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094112) ↗
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.
Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME, Price WA, Santella JB, Wells GJ, Wexler RR.
J Med Chem (1991) 34 : 2525 -2547
PubMed 1875348 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 6.40 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL315094 — — 1 7.92
CHEMBL191 LOSARTAN 4.0 1 7.72
CHEMBL85692 — — 1 7.72
CHEMBL308493 — — 1 7.70
CHEMBL313715 — — 1 7.70
CHEMBL87755 — — 1 7.54
CHEMBL87343 — — 1 7.50
CHEMBL313779 — — 1 7.22
CHEMBL315594 — — 1 7.21
CHEMBL313928 — — 1 7.21
CHEMBL85984 — — 1 7.10
CHEMBL86041 — — 1 7.08
CHEMBL87315 — — 1 7.05
CHEMBL49170 — — 1 7.04
CHEMBL314673 — — 1 7.00
CHEMBL85435 — — 1 6.92
CHEMBL86067 — — 1 6.85
CHEMBL88017 — — 1 6.82
CHEMBL87339 — — 1 6.80
CHEMBL85601 — — 1 6.72
CHEMBL314363 — — 1 6.70
CHEMBL83505 — — 1 6.70
CHEMBL274447 — — 1 6.64
CHEMBL446095 — — 1 6.62
CHEMBL83409 — — 1 6.60
CHEMBL315724 — — 1 6.58
CHEMBL313130 — — 1 6.58
CHEMBL86120 — — 1 6.57
CHEMBL86207 — — 1 6.55
CHEMBL310619 — — 1 6.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL315094 — IC50 = 12.0 nM 7.92
CHEMBL191 LOSARTAN IC50 = 19.0 nM 7.72
CHEMBL85692 — IC50 = 19.0 nM 7.72
CHEMBL308493 — IC50 = 20.0 nM 7.70
CHEMBL313715 — IC50 = 20.0 nM 7.70
CHEMBL87755 — IC50 = 29.0 nM 7.54
CHEMBL87343 — IC50 = 32.0 nM 7.50
CHEMBL313779 — IC50 = 60.0 nM 7.22
CHEMBL315594 — IC50 = 61.0 nM 7.21
CHEMBL313928 — IC50 = 62.0 nM 7.21
CHEMBL85984 — IC50 = 80.0 nM 7.10
CHEMBL86041 — IC50 = 83.0 nM 7.08
CHEMBL87315 — IC50 = 90.0 nM 7.05
CHEMBL49170 — IC50 = 92.0 nM 7.04
CHEMBL314673 — IC50 = 99.0 nM 7.00
CHEMBL85435 — IC50 = 120.0 nM 6.92
CHEMBL86067 — IC50 = 140.0 nM 6.85
CHEMBL88017 — IC50 = 150.0 nM 6.82
CHEMBL87339 — IC50 = 160.0 nM 6.80
CHEMBL85601 — IC50 = 190.0 nM 6.72
CHEMBL314363 — IC50 = 200.0 nM 6.70
CHEMBL83505 — IC50 = 200.0 nM 6.70
CHEMBL274447 — IC50 = 230.0 nM 6.64
CHEMBL446095 — IC50 = 240.0 nM 6.62
CHEMBL83409 — IC50 = 250.0 nM 6.60
CHEMBL315724 — IC50 = 260.0 nM 6.58
CHEMBL313130 — IC50 = 260.0 nM 6.58
CHEMBL86120 — IC50 = 270.0 nM 6.57
CHEMBL86207 — IC50 = 280.0 nM 6.55
CHEMBL310619 — IC50 = 290.0 nM 6.54
CHEMBL312950 — IC50 = 300.0 nM 6.52
CHEMBL315386 — IC50 = 330.0 nM 6.48
CHEMBL87553 — IC50 = 340.0 nM 6.47
CHEMBL312831 — IC50 = 370.0 nM 6.43
CHEMBL314818 — IC50 = 380.0 nM 6.42
CHEMBL82799 — IC50 = 390.0 nM 6.41
CHEMBL82445 — IC50 = 410.0 nM 6.39
CHEMBL280530 — IC50 = 490.0 nM 6.31
CHEMBL82814 — IC50 = 510.0 nM 6.29
CHEMBL419672 — IC50 = 580.0 nM 6.24
CHEMBL313827 — IC50 = 600.0 nM 6.22
CHEMBL82791 — IC50 = 660.0 nM 6.18
CHEMBL315711 — IC50 = 700.0 nM 6.16
CHEMBL420778 — IC50 = 700.0 nM 6.16
CHEMBL85655 — IC50 = 940.0 nM 6.03
CHEMBL85479 — IC50 = 980.0 nM 6.01
CHEMBL315247 — IC50 = 1300.0 nM 5.89
CHEMBL86121 — IC50 = 1300.0 nM 5.89
CHEMBL87391 — IC50 = 1700.0 nM 5.77
CHEMBL313927 — IC50 = 1800.0 nM 5.75