Assay Detail

CHEMBL651594

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of BALB/MK mouse epidermal keratinocyte proliferation

ChEMBL ↗

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Target

Balb/MK (CHEMBL614065) ↗

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Primary target Balb/MK

CHEMBL614065

Anchored from Assay target.

Protein identity Balb/MK

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	Balb/MK
Confidence	1 — Organism
Curated By	Expert

Target

Balb/MK (CHEMBL614065) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.

Trinks U, Buchdunger E, Furet P, Kump W, Mett H, Meyer T, Müller M, Regenass U, Rihs G, Lydon N.
J Med Chem (1994) 37 : 1015 -1027
PubMed 8151612 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.94	4.94

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL268868	DAPH	—	1	4.94

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL268868	DAPH	IC50	=	11500.0	nM	4.94