Assay Detail
Functional
CHEMBL651597
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Inhibition of Ras farnesylation in Human Ha-Ras-transformed BALB/c 3T3 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.26 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29982 | — | — | 1 | 7.80 |
| CHEMBL280976 | — | — | 1 | 6.72 |
| CHEMBL29980 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29982 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL280976 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL29980 | — | EC50 | > | 100.0 | nM | - |