Assay Detail
Functional
CHEMBL651598
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Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.03 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280847 | — | — | 1 | 9.30 |
| CHEMBL30059 | — | — | 1 | 8.41 |
| CHEMBL282161 | — | — | 1 | 8.40 |
| CHEMBL29633 | — | — | 1 | 7.55 |
| CHEMBL30118 | — | — | 1 | 7.51 |
| CHEMBL430073 | — | — | 1 | 7.01 |
| CHEMBL27677 | — | — | 1 | - |
| CHEMBL29619 | — | — | 1 | - |
| CHEMBL29980 | — | — | 1 | - |
| CHEMBL29503 | — | — | 1 | - |
| CHEMBL282166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280847 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL30059 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL282161 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL29633 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL30118 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL430073 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL27677 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL29619 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL29980 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL29503 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL282166 | — | EC50 | > | 100.0 | nM | - |