Assay Detail
Functional
CHEMBL651610
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Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitro
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cercopithecidae |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 8.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88740 | — | — | 1 | 9.00 |
| CHEMBL92487 | — | — | 1 | 8.70 |
| CHEMBL92050 | — | — | 1 | 8.70 |
| CHEMBL42314 | — | — | 1 | 8.52 |
| CHEMBL423503 | — | — | 1 | 8.52 |
| CHEMBL92430 | — | — | 1 | 8.40 |
| CHEMBL91779 | — | — | 1 | 8.30 |
| CHEMBL91185 | — | — | 1 | 8.22 |
| CHEMBL329334 | — | — | 1 | 8.15 |
| CHEMBL90824 | — | — | 1 | 8.10 |
| CHEMBL315986 | — | — | 1 | 8.05 |
| CHEMBL88931 | — | — | 1 | 8.00 |
| CHEMBL313647 | — | — | 1 | 7.96 |
| CHEMBL414218 | — | — | 1 | 7.92 |
| CHEMBL90254 | — | — | 1 | 7.72 |
| CHEMBL288436 | — | — | 1 | 7.42 |
| CHEMBL420249 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88740 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL92487 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL92050 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL42314 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL423503 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL92430 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL91779 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL91185 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL329334 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL90824 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL315986 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL88931 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL313647 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL414218 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL90254 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL288436 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL420249 | — | EC50 | = | 154.0 | nM | 6.81 |