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Assay Detail

CHEMBL651702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells
ChEMBL ↗
74
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type HEK293
Confidence 8 — Homologous single protein target
Curated By Expert

Target

C-C chemokine receptor type 1 (CHEMBL2413) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of novel non-peptide CCR1 receptor antagonists.
Ng HP, May K, Bauman JG, Ghannam A, Islam I, Liang M, Horuk R, Hesselgesser J, Snider RM, Perez HD, Morrissey MM.
J Med Chem (1999) 42 : 4680 -4694
PubMed 10579830 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 74 6.69 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL356099 — — 1 8.22
CHEMBL141127 — — 1 8.10
CHEMBL142752 — — 1 8.05
CHEMBL143374 — — 1 7.66
CHEMBL143350 — — 1 7.66
CHEMBL143492 — — 1 7.62
CHEMBL435485 — — 1 7.54
CHEMBL142925 — — 1 7.50
CHEMBL344324 — — 1 7.48
CHEMBL343511 — — 1 7.47
CHEMBL142318 — — 1 7.36
CHEMBL433746 — — 1 7.35
CHEMBL142191 — — 1 7.29
CHEMBL34166 BERLEX COMPOUND — 1 7.28
CHEMBL343680 — — 1 7.28
CHEMBL143059 — — 1 7.27
CHEMBL143173 — — 2 7.27
CHEMBL344073 — — 1 7.25
CHEMBL142468 — — 1 7.13
CHEMBL142199 — — 1 7.11
CHEMBL143499 — — 1 7.04
CHEMBL343028 — — 1 7.03
CHEMBL344989 — — 1 7.01
CHEMBL142620 — — 1 7.00
CHEMBL142004 — — 1 6.94
CHEMBL143194 — — 1 6.90
CHEMBL346205 — — 1 6.89
CHEMBL357434 — — 1 6.89
CHEMBL2112832 — — 1 6.87
CHEMBL344075 — — 1 6.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL356099 — Ki = 6.0 nM 8.22
CHEMBL141127 — Ki = 8.0 nM 8.10
CHEMBL142752 — Ki = 9.0 nM 8.05
CHEMBL143374 — Ki = 22.0 nM 7.66
CHEMBL143350 — Ki = 22.0 nM 7.66
CHEMBL143492 — Ki = 24.0 nM 7.62
CHEMBL435485 — Ki = 29.0 nM 7.54
CHEMBL142925 — Ki = 32.0 nM 7.50
CHEMBL344324 — Ki = 33.0 nM 7.48
CHEMBL343511 — Ki = 34.0 nM 7.47
CHEMBL142318 — Ki = 44.0 nM 7.36
CHEMBL433746 — Ki = 45.0 nM 7.35
CHEMBL142191 — Ki = 51.0 nM 7.29
CHEMBL343680 — Ki = 53.0 nM 7.28
CHEMBL34166 BERLEX COMPOUND Ki = 52.0 nM 7.28
CHEMBL143059 — Ki = 54.0 nM 7.27
CHEMBL143173 — Ki = 54.0 nM 7.27
CHEMBL344073 — Ki = 56.0 nM 7.25
CHEMBL143173 — Ki = 71.0 nM 7.15
CHEMBL142468 — Ki = 74.0 nM 7.13
CHEMBL142199 — Ki = 78.0 nM 7.11
CHEMBL143499 — Ki = 92.0 nM 7.04
CHEMBL343028 — Ki = 93.0 nM 7.03
CHEMBL344989 — Ki = 98.0 nM 7.01
CHEMBL142620 — Ki = 99.0 nM 7.00
CHEMBL142004 — Ki = 116.0 nM 6.94
CHEMBL143194 — Ki = 125.0 nM 6.90
CHEMBL346205 — Ki = 128.0 nM 6.89
CHEMBL357434 — Ki = 130.0 nM 6.89
CHEMBL2112832 — Ki = 136.0 nM 6.87
CHEMBL344075 — Ki = 153.0 nM 6.82
CHEMBL341840 — Ki = 156.0 nM 6.81
CHEMBL141829 — Ki = 164.0 nM 6.79
CHEMBL142244 — Ki = 203.0 nM 6.69
CHEMBL342444 — Ki = 206.0 nM 6.69
CHEMBL141020 — Ki = 206.0 nM 6.69
CHEMBL143814 — Ki = 224.0 nM 6.65
CHEMBL143449 — Ki = 234.0 nM 6.63
CHEMBL141387 — Ki = 236.0 nM 6.63
CHEMBL142676 — Ki = 233.0 nM 6.63
CHEMBL125111 — Ki = 244.0 nM 6.61
CHEMBL356764 — Ki = 306.0 nM 6.51
CHEMBL143772 — Ki = 330.0 nM 6.48
CHEMBL141713 — Ki = 347.0 nM 6.46
CHEMBL141817 — Ki = 359.0 nM 6.45
CHEMBL357445 — Ki = 366.0 nM 6.44
CHEMBL142160 — Ki = 371.0 nM 6.43
CHEMBL142713 — Ki = 385.0 nM 6.42
CHEMBL143266 — Ki = 400.0 nM 6.40
CHEMBL356718 — Ki = 406.0 nM 6.39