Assay Detail
Binding
CHEMBL651726
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50 percent inhibitory concentration of Butyrylcholinesterase (BChE)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.97 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443499 | — | — | 1 | 6.77 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443499 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL26505 | APROFENE | IC50 | = | 6700.0 | nM | 5.17 |