Assay Detail
Binding
CHEMBL651916
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Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a novel CCR3 selective antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.24 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277930 | — | — | 1 | 9.05 |
| CHEMBL282285 | — | — | 1 | 6.58 |
| CHEMBL20532 | — | — | 1 | 6.35 |
| CHEMBL20921 | — | — | 1 | 5.72 |
| CHEMBL21143 | — | — | 1 | 5.44 |
| CHEMBL21199 | — | — | 1 | 5.38 |
| CHEMBL20539 | — | — | 1 | 5.15 |
| CHEMBL266181 | — | — | 1 | - |
| CHEMBL20612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277930 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL282285 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL20532 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL20921 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL21143 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL21199 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL20539 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL266181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL20612 | — | IC50 | > | 10000.0 | nM | - |