Assay Detail
Functional
CHEMBL651917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.47 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138134 | — | — | 1 | 6.58 |
| CHEMBL3138187 | — | — | 1 | 6.58 |
| CHEMBL3138115 | — | — | 1 | 5.40 |
| CHEMBL3138437 | — | — | 1 | 5.24 |
| CHEMBL3138118 | — | — | 1 | 5.04 |
| CHEMBL3137848 | — | — | 1 | 5.00 |
| CHEMBL3138130 | — | — | 1 | 5.00 |
| CHEMBL3138123 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138134 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3138187 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3138115 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3138437 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3138118 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3137848 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3138130 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3138123 | — | IC50 | = | 12700.0 | nM | 4.90 |