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Assay Detail

CHEMBL652053

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for its binding affinity to CHO cells expressing the cloned human Beta-3 adrenergic receptor in the presence of [125I]iodocyanopindolol
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Beta-3 adrenergic receptor (CHEMBL246)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Beta 3 agonists. Part 1: evolution from inception to BMS-194449.
Washburn WN, Sher PM, Poss KM, Girotra RN, McCann PJ, Gavai AV, Mikkilineni AB, Mathur A, Cheng P, Dejneka TC, Sun CQ, Wang TC, Harper TW, Russell AD, Slusarchyk DA, Skwish S, Allen GT, Hillyer DE, Frohlich BH, Abboa-Offei BE, Cap M, Waldron TL, George RJ, Tesfamariam B, Ciosek CP, Ryono D, Young DA, Dickinson KE, Seymour AA, Arbeeny CM, Gregg RE.
Bioorg Med Chem Lett (2001) 11 : 3035 -3039
PubMed 11714605 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.70 4.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL32590 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL32590 Ki = 20000.0 nM 4.70