Assay Detail
Binding
CHEMBL652055
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Ability to bind to human Beta-3 adrenergic receptor using membranes of stably transfected CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carboxyl-promoted enhancement of selectivity for the 3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-3 binding selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.35 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38538 | — | — | 1 | 6.09 |
| CHEMBL284782 | — | — | 1 | 6.02 |
| CHEMBL38486 | — | — | 1 | 5.94 |
| CHEMBL39596 | — | — | 1 | 5.71 |
| CHEMBL41113 | — | — | 1 | 5.67 |
| CHEMBL38569 | — | — | 1 | 5.43 |
| CHEMBL290752 | — | — | 1 | 4.96 |
| CHEMBL40966 | — | — | 1 | 4.73 |
| CHEMBL39334 | — | — | 1 | 4.70 |
| CHEMBL41948 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38538 | — | Ki | = | 806.0 | nM | 6.09 |
| CHEMBL284782 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL38486 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL39596 | — | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL41113 | — | Ki | = | 2140.0 | nM | 5.67 |
| CHEMBL38569 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL290752 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL40966 | — | Ki | = | 18800.0 | nM | 4.73 |
| CHEMBL39334 | — | Ki | = | 19900.0 | nM | 4.70 |
| CHEMBL41948 | — | Ki | = | 55300.0 | nM | 4.26 |