Assay Detail
Binding
CHEMBL652056
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Compound was tested for its binding affinity against beta3 adrenergic receptor in CHO cell membrane using [125I]iodocyanopindolol as the radioligand.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
BMS-187257, a potent, selective, and novel heterocyclic 3 adrenergic receptor agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.79 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419085 | — | — | 1 | 6.41 |
| CHEMBL308150 | — | — | 1 | 6.28 |
| CHEMBL72169 | — | — | 1 | 6.12 |
| CHEMBL284782 | — | — | 1 | 6.02 |
| CHEMBL73220 | — | — | 1 | 5.45 |
| CHEMBL72168 | — | — | 1 | 4.44 |
| CHEMBL72060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419085 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL308150 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL72169 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL284782 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL73220 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL72168 | — | Ki | = | 36500.0 | nM | 4.44 |
| CHEMBL72060 | — | Ki | = | 146000.0 | nM | - |