Assay Detail
Functional
CHEMBL652104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
MDR-modulating activity as a measure to inhibit P-glycoprotein (PGP) mediated transmembrane transport in human T-lymphoblast cell line CEM vcr 1000 using the daunomycin efflux assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM/VCR-1000 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological activity of the stereoisomers of GP-88, a propafenone-type modulator of multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.17 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788268 | — | — | 1 | 6.58 |
| CHEMBL1322675 | — | — | 1 | 6.43 |
| CHEMBL170328 | — | — | 1 | 6.24 |
| CHEMBL168258 | — | — | 1 | 6.11 |
| CHEMBL349429 | — | — | 1 | 5.85 |
| CHEMBL353163 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788268 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1322675 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL170328 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL168258 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL349429 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL353163 | — | EC50 | = | 1560.0 | nM | 5.81 |