Assay Detail
Functional
CHEMBL652296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Uterus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.30 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.75 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | — | 1 | 8.62 |
| CHEMBL171432 | — | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL1137 | 4-HYDROXYPROPRANOLOL SULFATE | Kd | = | 2.399 | nM | 8.62 |
| CHEMBL171432 | — | Kd | = | 29.51 | nM | 7.53 |