Assay Detail
Binding
CHEMBL652310
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In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL813 | EPROSARTAN | 4.0 | 1 | 9.00 |
| CHEMBL216061 | — | — | 1 | 8.89 |
| CHEMBL40089 | — | — | 1 | 7.68 |
| CHEMBL291086 | — | — | 1 | 7.51 |
| CHEMBL289543 | — | — | 1 | 6.36 |
| CHEMBL287762 | — | — | 1 | 6.21 |
| CHEMBL36846 | — | — | 1 | 5.58 |
| CHEMBL39349 | — | — | 1 | 5.22 |
| CHEMBL291114 | — | — | 1 | 5.05 |
| CHEMBL39345 | — | — | 1 | 4.92 |
| CHEMBL25528 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL813 | EPROSARTAN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL216061 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL40089 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL291086 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL289543 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL287762 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL36846 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL39349 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL291114 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL39345 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL25528 | — | IC50 | = | 43000.0 | nM | 4.37 |