Assay Detail
Binding
CHEMBL652311
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In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.62 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385189 | — | — | 1 | 9.96 |
| CHEMBL37679 | — | — | 1 | 8.84 |
| CHEMBL287936 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385189 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL37679 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL287936 | — | IC50 | = | 90.0 | nM | 7.05 |