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Assay Detail

CHEMBL652340

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Functional
Agonism against Beta-3 adrenergic receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Beta-3 adrenergic receptor (CHEMBL246)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.
Naylor EM, Colandrea VJ, Candelore MR, Cascieri MA, Colwell LF, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Strader CD, Tota L, Wang PR, Wyvratt MJ, Fisher MH, Weber AE.
Bioorg Med Chem Lett (1998) 8 : 3087 -3092
PubMed 9873681 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 7.58 9.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL12998 L-755507 1 9.37
CHEMBL323113 1 8.85
CHEMBL104193 1 8.80
CHEMBL294042 L-749372 1 8.44
CHEMBL57486 1 8.20
CHEMBL320138 1 7.75
CHEMBL318165 1 7.75
CHEMBL321957 1 7.57
CHEMBL318802 1 7.42
CHEMBL320228 1 7.31
CHEMBL64697 1 7.25
CHEMBL104981 1 7.25
CHEMBL104061 1 7.17
CHEMBL106487 1 7.17
CHEMBL104076 1 7.17
CHEMBL105968 1 7.11
CHEMBL106746 1 7.00
CHEMBL104222 1 6.82
CHEMBL104180 1 6.80
CHEMBL284782 1 6.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL12998 L-755507 EC50 = 0.43 nM 9.37
CHEMBL323113 EC50 = 1.4 nM 8.85
CHEMBL104193 EC50 = 1.6 nM 8.80
CHEMBL294042 L-749372 EC50 = 3.6 nM 8.44
CHEMBL57486 EC50 = 6.3 nM 8.20
CHEMBL320138 EC50 = 18.0 nM 7.75
CHEMBL318165 EC50 = 18.0 nM 7.75
CHEMBL321957 EC50 = 27.0 nM 7.57
CHEMBL318802 EC50 = 38.0 nM 7.42
CHEMBL320228 EC50 = 49.0 nM 7.31
CHEMBL64697 EC50 = 56.0 nM 7.25
CHEMBL104981 EC50 = 56.0 nM 7.25
CHEMBL104061 EC50 = 68.0 nM 7.17
CHEMBL106487 EC50 = 67.0 nM 7.17
CHEMBL104076 EC50 = 67.0 nM 7.17
CHEMBL105968 EC50 = 77.0 nM 7.11
CHEMBL106746 EC50 = 100.0 nM 7.00
CHEMBL104222 EC50 = 150.0 nM 6.82
CHEMBL104180 EC50 = 160.0 nM 6.80
CHEMBL284782 EC50 = 450.0 nM 6.35