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Assay Detail

CHEMBL652401

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Chemosensitivity against DT-diaphorase deficient BEcell lines
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type BE
Confidence 1 — Organism
Curated By Expert

Target

BE (CHEMBL614798)
Type CELL-LINE
Organism Homo sapiens

Publication

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.
Phillips RM, Naylor MA, Jaffar M, Doughty SW, Everett SA, Breen AG, Choudry GA, Stratford IJ.
J Med Chem (1999) 42 : 4071 -4080
PubMed 10514277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.37 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329024 1 6.51
CHEMBL328916 1 6.44
CHEMBL328535 1 6.21
CHEMBL94033 1 5.98
CHEMBL73822 APAZIQUONE 3.0 1 5.90
CHEMBL307888 1 5.77
CHEMBL130223 1 5.74
CHEMBL77393 1 5.42
CHEMBL130409 1 5.00
CHEMBL338716 1 4.86
CHEMBL307665 1 4.86
CHEMBL308775 1 4.73
CHEMBL341425 1 4.72
CHEMBL74816 1 4.66
CHEMBL112472 1 4.62
CHEMBL133323 1 4.45
CHEMBL335032 1 -
CHEMBL93641 1 -
CHEMBL73067 1 -
CHEMBL306559 1 -
CHEMBL131446 1 -
CHEMBL133390 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329024 IC50 = 310.0 nM 6.51
CHEMBL328916 IC50 = 360.0 nM 6.44
CHEMBL328535 IC50 = 610.0 nM 6.21
CHEMBL94033 IC50 = 1040.0 nM 5.98
CHEMBL73822 APAZIQUONE IC50 = 1250.0 nM 5.90
CHEMBL307888 IC50 = 1700.0 nM 5.77
CHEMBL130223 IC50 = 1830.0 nM 5.74
CHEMBL77393 IC50 = 3810.0 nM 5.42
CHEMBL130409 IC50 = 9980.0 nM 5.00
CHEMBL338716 IC50 = 13950.0 nM 4.86
CHEMBL307665 IC50 = 13770.0 nM 4.86
CHEMBL308775 IC50 = 18690.0 nM 4.73
CHEMBL341425 IC50 = 18840.0 nM 4.72
CHEMBL74816 IC50 = 21710.0 nM 4.66
CHEMBL112472 IC50 = 24110.0 nM 4.62
CHEMBL133323 IC50 = 35440.0 nM 4.45
CHEMBL335032 IC50 > 40000.0 nM -
CHEMBL93641 IC50 > 40000.0 nM -
CHEMBL73067 IC50 > 40000.0 nM -
CHEMBL306559 IC50 > 40000.0 nM -
CHEMBL131446 IC50 > 40000.0 nM -
CHEMBL133390 IC50 > 40000.0 nM -