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Assay Detail

CHEMBL652403

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against BE human colon carcinoma cell lines BE-WT(No NQO1 activity)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BE-WT
Confidence 1 — Organism
Curated By Intermediate

Target

BE-WT (CHEMBL614799)
Type CELL-LINE

Publication

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.
Swann E, Barraja P, Oberlander AM, Gardipee WT, Hudnott AR, Beall HD, Moody CJ.
J Med Chem (2001) 44 : 3311 -3319
PubMed 11563930 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.26 5.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL112915 1 5.98
CHEMBL113131 1 5.82
CHEMBL331813 1 5.82
CHEMBL326499 1 5.42
CHEMBL93799 1 5.26
CHEMBL320778 1 4.99
CHEMBL331589 1 4.46
CHEMBL113458 1 4.31
CHEMBL320563 1 -
CHEMBL321614 1 -
CHEMBL73067 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL112915 IC50 = 1050.0 nM 5.98
CHEMBL113131 IC50 = 1500.0 nM 5.82
CHEMBL331813 IC50 = 1500.0 nM 5.82
CHEMBL326499 IC50 = 3800.0 nM 5.42
CHEMBL93799 IC50 = 5500.0 nM 5.26
CHEMBL320778 IC50 = 10300.0 nM 4.99
CHEMBL331589 IC50 = 34400.0 nM 4.46
CHEMBL113458 IC50 = 49000.0 nM 4.31
CHEMBL320563 IC50 > 50000.0 nM -
CHEMBL321614 IC50 > 50000.0 nM -
CHEMBL73067 IC50 > 50000.0 nM -