Assay Detail
Functional
CHEMBL652523
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sensitization of CA1 pyramidal neurons to depolarizations by L-AP6 before exposure to quisqualic acid
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pyramidal neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.96 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126608 | — | — | 1 | 4.96 |
| CHEMBL279956 | QUISQUALATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126608 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL279956 | QUISQUALATE | IC50 | > | 10000.0 | nM | - |