Assay Detail
Functional
CHEMBL652588
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to effect a 50% relaxation of ferret detrusor basal tone
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mustela putorius furo |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.16 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284782 | — | — | 1 | 8.66 |
| CHEMBL13560 | — | — | 1 | 8.42 |
| CHEMBL544427 | — | — | 1 | 8.13 |
| CHEMBL3349532 | — | — | 1 | 6.31 |
| CHEMBL2079543 | — | — | 1 | 6.21 |
| CHEMBL2079599 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284782 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL13560 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL544427 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3349532 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2079543 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2079599 | — | EC50 | = | 5800.0 | nM | 5.24 |