Assay Detail
Functional
CHEMBL652606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HSV-2 in baby hamster kidney cell
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | herpes simplex virus |
| Cell Type | kidney |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Ribonucleoside-diphosphate reductase RR1 (CHEMBL2095215) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase: a new class of antiviral agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.85 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330978 | — | — | 1 | 5.38 |
| CHEMBL263789 | — | — | 1 | 5.19 |
| CHEMBL331518 | — | — | 1 | 5.14 |
| CHEMBL121839 | — | — | 1 | 4.85 |
| CHEMBL409908 | — | — | 1 | 4.52 |
| CHEMBL120264 | — | — | 1 | 4.46 |
| CHEMBL431654 | — | — | 1 | 4.41 |
| CHEMBL121447 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330978 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL263789 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL331518 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL121839 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL409908 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL120264 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL431654 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL121447 | — | EC50 | = | 150000.0 | nM | - |