Assay Detail
Binding
CHEMBL652637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of potent bradykinin agonists containing a benzothiazepine moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.49 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028850 | ICATIBANT | 4.0 | 1 | 10.19 |
| CHEMBL406291 | BRADYKININ | 2.0 | 1 | 9.19 |
| CHEMBL2112698 | — | — | 1 | 9.15 |
| CHEMBL413386 | — | — | 1 | 7.89 |
| CHEMBL2105864 | LABRADIMIL | 2.0 | 1 | 7.72 |
| CHEMBL2111889 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028850 | ICATIBANT | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL406291 | BRADYKININ | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL2112698 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL413386 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2105864 | LABRADIMIL | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2111889 | — | Ki | = | 162.0 | nM | 6.79 |