Assay Detail
Binding
CHEMBL652643
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Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.51 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142396 | — | — | 1 | 10.10 |
| CHEMBL406291 | BRADYKININ | 2.0 | 1 | 9.96 |
| CHEMBL412824 | — | — | 1 | 9.40 |
| CHEMBL408846 | — | — | 1 | 8.36 |
| CHEMBL3085458 | — | — | 1 | 8.04 |
| CHEMBL3142391 | — | — | 1 | 7.21 |
| CHEMBL216618 | — | — | 1 | 6.49 |
| CHEMBL80472 | — | — | 1 | - |
| CHEMBL2369827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142396 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL406291 | BRADYKININ | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL412824 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL408846 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3085458 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3142391 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL216618 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL80472 | — | Ki | > | 10.0 | nM | - |
| CHEMBL2369827 | — | Ki | > | 10.0 | nM | - |