Assay Detail
Binding
CHEMBL652714
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In vitro for binding affinity against beta adrenergic receptor in rat cortex
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500 | PINDOLOL | 4.0 | 1 | 9.00 |
| CHEMBL37314 | — | — | 1 | 8.70 |
| CHEMBL38205 | — | — | 1 | 8.52 |
| CHEMBL37989 | — | — | 1 | 8.30 |
| CHEMBL288841 | — | — | 1 | 8.30 |
| CHEMBL36159 | — | — | 1 | 8.30 |
| CHEMBL37236 | — | — | 1 | 8.22 |
| CHEMBL37292 | — | — | 1 | 7.60 |
| CHEMBL37235 | — | — | 1 | 7.22 |
| CHEMBL36495 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500 | PINDOLOL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL37314 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL38205 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL37989 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL288841 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL36159 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL37236 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL37292 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL37235 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL36495 | — | Ki | = | 125.0 | nM | 6.90 |