Assay Detail
Binding
CHEMBL652805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against Alpha-1A adrenergic receptor in isolated prostate tissue of dog
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Prostate gland |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.81 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356584 | — | — | 1 | 8.89 |
| CHEMBL358595 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356584 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL358595 | — | Ki | = | 1.9 | nM | 8.72 |