Assay Detail
Binding
CHEMBL652818
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In vitro binding affinity at human Alpha-1A adrenergic receptor.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.13 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303464 | — | — | 1 | 8.85 |
| CHEMBL25467 | — | — | 1 | 7.44 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.60 |
| CHEMBL98241 | — | — | 1 | 6.53 |
| CHEMBL320397 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303464 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL25467 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL13647 | BMY-7378 | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL98241 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL320397 | — | Ki | = | 616.0 | nM | 6.21 |