Assay Detail
Binding
CHEMBL652820
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Binding affinity for human Alpha-1A adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.04 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13735 | — | — | 1 | 9.46 |
| CHEMBL13903 | — | — | 1 | 9.06 |
| CHEMBL268758 | A-119637 | — | 1 | 8.58 |
| CHEMBL13754 | — | — | 1 | 8.58 |
| CHEMBL14213 | — | — | 1 | 8.51 |
| CHEMBL13856 | A-123189 | — | 1 | 8.38 |
| CHEMBL14199 | — | — | 1 | 8.07 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.89 |
| CHEMBL98241 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13735 | — | Ki | = | 0.344 | nM | 9.46 |
| CHEMBL13903 | — | Ki | = | 0.868 | nM | 9.06 |
| CHEMBL268758 | A-119637 | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL13754 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL14213 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL13856 | A-123189 | Ki | = | 4.17 | nM | 8.38 |
| CHEMBL14199 | — | Ki | = | 8.49 | nM | 8.07 |
| CHEMBL13647 | BMY-7378 | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL98241 | — | Ki | = | 14900.0 | nM | 4.83 |