Assay Detail
Binding
CHEMBL652822
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Binding affinity was determined for the alpha-1A adrenergic receptor
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.90 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.24 |
| CHEMBL356829 | — | — | 1 | 9.08 |
| CHEMBL279436 | — | — | 1 | 8.73 |
| CHEMBL347499 | — | — | 1 | 8.72 |
| CHEMBL151878 | — | — | 1 | 8.66 |
| CHEMBL147077 | — | — | 3 | 8.62 |
| CHEMBL146815 | — | — | 1 | 8.59 |
| CHEMBL347559 | — | — | 1 | 8.54 |
| CHEMBL41844 | — | — | 1 | 8.45 |
| CHEMBL347501 | — | — | 1 | 8.44 |
| CHEMBL346649 | — | — | 1 | 8.43 |
| CHEMBL148552 | — | — | 1 | 8.38 |
| CHEMBL151825 | — | — | 1 | 8.32 |
| CHEMBL357681 | — | — | 1 | 8.32 |
| CHEMBL357061 | — | — | 1 | 8.27 |
| CHEMBL358406 | — | — | 1 | 8.22 |
| CHEMBL358253 | — | — | 1 | 8.21 |
| CHEMBL355910 | — | — | 1 | 8.21 |
| CHEMBL149263 | — | — | 1 | 8.11 |
| CHEMBL151045 | — | — | 1 | 8.11 |
| CHEMBL356623 | — | — | 1 | 8.04 |
| CHEMBL347522 | — | — | 1 | 7.57 |
| CHEMBL151668 | — | — | 1 | 7.23 |
| CHEMBL359375 | — | — | 1 | 7.20 |
| CHEMBL150696 | — | — | 1 | 6.34 |
| CHEMBL146983 | — | — | 1 | 5.60 |
| CHEMBL356923 | — | — | 1 | 5.42 |
| CHEMBL150743 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL356829 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL279436 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL347499 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL151878 | — | Ki | = | 2.19 | nM | 8.66 |
| CHEMBL147077 | — | Ki | = | 2.42 | nM | 8.62 |
| CHEMBL146815 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL347559 | — | Ki | = | 2.88 | nM | 8.54 |
| CHEMBL41844 | — | Ki | = | 3.58 | nM | 8.45 |
| CHEMBL347501 | — | Ki | = | 3.66 | nM | 8.44 |
| CHEMBL346649 | — | Ki | = | 3.72 | nM | 8.43 |
| CHEMBL147077 | — | Ki | = | 3.94 | nM | 8.40 |
| CHEMBL148552 | — | Ki | = | 4.17 | nM | 8.38 |
| CHEMBL151825 | — | Ki | = | 4.79 | nM | 8.32 |
| CHEMBL357681 | — | Ki | = | 4.82 | nM | 8.32 |
| CHEMBL357061 | — | Ki | = | 5.41 | nM | 8.27 |
| CHEMBL358406 | — | Ki | = | 5.98 | nM | 8.22 |
| CHEMBL355910 | — | Ki | = | 6.12 | nM | 8.21 |
| CHEMBL358253 | — | Ki | = | 6.17 | nM | 8.21 |
| CHEMBL149263 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL151045 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL356623 | — | Ki | = | 9.05 | nM | 8.04 |
| CHEMBL347522 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL151668 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL359375 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL150696 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL147077 | — | Ki | = | 607.0 | nM | 6.22 |
| CHEMBL146983 | — | Ki | = | 2512.0 | nM | 5.60 |
| CHEMBL356923 | — | Ki | = | 3770.0 | nM | 5.42 |
| CHEMBL150743 | — | Ki | = | 4330.0 | nM | 5.36 |