Assay Detail
Binding
CHEMBL652838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Class B (CCRA) beta-Lactamases
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteroides fragilis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metallo-beta-lactamase type 2 (CHEMBL4840) ↗| Type | SINGLE PROTEIN |
| Organism | Bacteroides fragilis |
Publication
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.04 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124416 | — | — | 1 | 7.85 |
| CHEMBL263746 | — | — | 1 | 7.18 |
| CHEMBL122450 | — | — | 1 | 6.62 |
| CHEMBL331090 | — | — | 1 | 6.50 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124416 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL263746 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL122450 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL331090 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 400000.0 | nM | - |