Assay Detail
Binding
CHEMBL652841
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Inhibitory activity against AmpC (class C) beta-lactamase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.79 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6469 | — | — | 1 | 6.57 |
| CHEMBL269471 | — | — | 1 | 6.55 |
| CHEMBL6678 | — | — | 1 | 6.55 |
| CHEMBL6533 | — | — | 1 | 6.44 |
| CHEMBL6461 | Ro-481220 | — | 1 | 5.95 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 4.32 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6469 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL269471 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL6678 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL6533 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL6461 | Ro-481220 | IC50 | = | 1133.0 | nM | 5.95 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL403 | SULBACTAM | IC50 | = | 65900.0 | nM | 4.18 |