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Assay Detail

CHEMBL652862

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for binding affinity against angiotensin II receptor in bovine adrenal cortex
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Adrenal cortex
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Type-1 angiotensin II receptor (CHEMBL3374)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Uracil-based angiotensin II receptor antagonists
Dorsch D, Mederski WW, Osswald M, Beier N, Schelling P
Bioorg Med Chem Lett (1995) 5 : 2071 -2076
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.05 8.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62269 1 8.03
CHEMBL65224 1 7.80
CHEMBL65503 1 7.70
CHEMBL416507 1 7.64
CHEMBL62936 1 7.60
CHEMBL304251 1 7.57
CHEMBL303822 1 7.47
CHEMBL292781 1 7.40
CHEMBL292316 1 7.36
CHEMBL305350 1 7.26
CHEMBL294358 1 7.21
CHEMBL304032 1 7.00
CHEMBL191 LOSARTAN 4.0 1 6.80
CHEMBL293001 1 6.28
CHEMBL294075 1 6.00
CHEMBL417410 1 5.62
CHEMBL64670 1 5.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62269 IC50 = 9.3 nM 8.03
CHEMBL65224 IC50 = 16.0 nM 7.80
CHEMBL65503 IC50 = 20.0 nM 7.70
CHEMBL416507 IC50 = 23.0 nM 7.64
CHEMBL62936 IC50 = 25.0 nM 7.60
CHEMBL304251 IC50 = 27.0 nM 7.57
CHEMBL303822 IC50 = 34.0 nM 7.47
CHEMBL292781 IC50 = 40.0 nM 7.40
CHEMBL292316 IC50 = 44.0 nM 7.36
CHEMBL305350 IC50 = 55.0 nM 7.26
CHEMBL294358 IC50 = 62.0 nM 7.21
CHEMBL304032 IC50 = 100.0 nM 7.00
CHEMBL191 LOSARTAN IC50 = 160.0 nM 6.80
CHEMBL293001 IC50 = 520.0 nM 6.28
CHEMBL294075 IC50 = 1000.0 nM 6.00
CHEMBL417410 IC50 = 2400.0 nM 5.62
CHEMBL64670 IC50 = 6600.0 nM 5.18